Microspheres and nanospheres are becoming an indispensable tool for ultra-sensitive assays, multiplex detection, in vitro and in vivo imaging, drug delivery and other scientific research. Phosphorex develops and supplies various types of microspheres and nanospheres for a broad range of scientific and biomedical applications. Our standard products include pure polymer, fluorescent, phosphorescent and color microspheres with sizes ranging from 20 nm to 1,000 microns. Many of these spheres are surface modified so they can be conveniently conjugated to antibodies, proteins, peptides, oligonucleotides and other biomolecules.
In addition, we also provide custom microspheres and bioconjugation services. We can encapsulate customer specified dyes, drugs and other molecules into microspheres and nanospheres. We can also attach various types of biomolecules to microspheres and nanospheres. Please contact us for details.
Our products can be divided into four categories:
Plain Polymer Microspheres and Nanospheres
PolyspherexTM microspheres and nanospheres are made from polystyrene, poly(methyl methacrylate), poly(acrylic acid), nylon, poly(lactic acid), PLGA, chitosan and many other synthetic and natural polymers. PLGA is an FDA-approved, biodegradable polymer and has been widely used in biomedical applications. Our featured products include plain and fluorescent PLGA micro- and nanospheres. Our mono-dispersed polystyrene microspheres and nanospheres are made via emulsion and dispersion polymerizations; some of them are surface functionalized with carboxyl groups for covalent conjugation.
Color Dyed Microspheres and Nanospheres
VisiblexTM color microspheres and nanospheres are made by dyeing uniform polystyrene spheres with color dyes. We offer blue, red and green microspheres with particle size ranging from 50 nm to 500 μm. Other colors and sizes are available on a custom basis.
Fluorescent Microsphere and Nanospheres
PLGA fluorescent microspheres and nanospheres are synthesized by encapsulating a green fluorescent dye in the PLGA matrix. They can be used for research in drug delivery. Call for availability of other fluorescent flavors.
Polystyrene fluorescent microspheres are uniform spheres dyed with fluorescent agents. We offer blue/violet, green, orange and red fluorescence.
Polystyrene fluorescent microspheres are uniform spheres dyed with fluorescent agents. We offer blue/violet, green, orange and red fluorescence.
Phosphorescent / Luminescent Nanospheres
Background interference can severely compromise the sensitivity of fluorescence-based immunoassays. One approach to address this problem is to use long-lived luminescence or phosphorescence. While fluorescent dyes typically have decay times of nanoseconds, our phosphorescent nanospheres may emit signals that can last up to milliseconds. Since background fluorescence decays much more rapidly than phosphorescence, it can be eliminated with time-resolved fluorescent (TRF) measurement. Thus our FosphexTM phosphorescent nanospheres can be used in TRF's for ultra-sensitive, background-free immunoassays. Other sizes are available on a custom basis.
To contact us, please call toll-free at 1-877-288-8010 or email us at info@phosphorex.com