Microspheres and nanospheres are becoming an indispensable tool for ultra-sensitive assays, multiplex detection, in vitro and in vivo imaging, and drug delivery. Phosphorex develops and supplies various types of microspheres and nanospheres for a broad range of scientific and biomedical applications. In addition to supplying pure polymer microspheres and nanospheres, we encapsulate fluorescent, phosphorescent, near-infrared and color dyes in various types of polymers to form functional particles with sizes ranging from 20 nm to over 1,000 microns. Many of these spheres are surface modified so they can be conveniently conjugated to antibodies, proteins, peptides, oligonucleotides and other biomolecules.
Our services include custom synthesis and conjugation. We can put customer specified dyes, drugs and other molecules into nanospheres or microspheres. We can also attach biomolecules of your selection to the spheres. Please contact us for details.
Our products can be divided into five categories:
Our products can be divided into five categories:
PolyspherexTM nanospheres and microspheres are made from polystyrene, poly(methyl methacrylate), poly(acrylic acid), polyacrylonitrile, poly(lactic acid), PLGA, chitosan and many other synthetic and natural polymers. PLGA is an FDA-approved, biodegradable polymer and has been widely used in drug applications. Our featured products include plain PLGA and fluorescent micro- and nanospheres.
VisiblexTM nanospheres and microspheres are made from visible color dyes with several colors to choose from.
Our FluorophorexTM nanospheres and microspheres emit extremely bright fluorescence. We feature four types of colors with each matching a specific excitation source.
Background interference can severely compromise the sensitivity of fluorescence-based immunoassays. One of the approaches to address this problem is to use phosphorescence. While fluorescent dyes typically have decay times of nanoseconds, our phosphorescent nanospheres may emit signals that can last up to milliseconds. Since background fluorescence decays much more rapidly than phosphorescence，it can be eliminated with time-resolved fluorescent (TRF) measurement. Thus our FosphexTM phosphorescent nanospheres can be used in TRF's for ultra-sensitive, background-free immunoassays.
The advent of optical molecular imaging has made it possible to visualize many biological events in vivo. It uses near-infrared light to detect pathologic conditions and tracks the progression and retrogression of diseases. The non-invasive, easy-to-use, highly specific method brings true hopes for early detection of cancer. Optical molecular imaging is also an indispensable tool in drug discovery. The monitoring of tumors and other molecular and cellular events in small animals provides a means of studying drug efficacy and disease progression, whereas traditional methods are time-consuming and do not provide in vivo results.
Along the advancement of molecular imaging, there is a growing need for optical contrast agents. Our NIRexTM nanospheres are stable in aqueous media and can be easily conjugated to various biomolecules. They typically have longer circulation times and less photobleaching than single-molecule dyes. Because near-infrared light can penetrate deeply in tissue, NIRexTM nanospheres are ideal contrast agents for in vivo optical and molecular imaging.
Along the advancement of molecular imaging, there is a growing need for optical contrast agents. Our NIRexTM nanospheres are stable in aqueous media and can be easily conjugated to various biomolecules. They typically have longer circulation times and less photobleaching than single-molecule dyes. Because near-infrared light can penetrate deeply in tissue, NIRexTM nanospheres are ideal contrast agents for in vivo optical and molecular imaging.
To contact us, please call toll-free at 1-877-288-8010 or email us at info@phosphorex.com