Modalities, Payloads & Drug Carriers
Expertise to Overcome Targeting and Biodistribution Barriers
Phosphorex brings deep expertise across advanced therapeutic modalities, diverse payloads, and leading particle-based drug carriers. From nucleic acids and gene-editing systems to peptides, proteins, and small molecules, we engineer tailored delivery strategies that overcome poor targeting and inefficient intracellular delivery. Leveraging LNPs, polymeric nanoparticles, polymeric microspheres, and hybrid systems, we deliver scalable solutions for emerging therapeutic classes while collaborating with clients to effectively address challenges such as potency, immunogenicity risks, and poor biodistribution.
Targeted Delivery Solutions Spanning Diverse Therapeutic Modalities
Across cell therapy, gene therapy, vaccines, immuno-oncology, and long-acting injectables, Phosphorex engineers particle-based delivery systems that enable precise targeting, efficient intracellular delivery, and sustained therapeutic performance across a wide range of clinical applications.
ex vivo
Cell Therapy
Cell Therapy
Advanced LNP platforms enabling efficient delivery of CAR constructs and gene editing cargos into lymphocytes for scalable cell therapy development.
ex vivo
Cell Therapy
Cell Therapy
Advanced LNP platforms enabling efficient delivery of CAR constructs and gene editing cargos into lymphocytes for scalable cell therapy development.
in vivo
Cell Engineering
Cell Engineering
Targeted LNP systems enabling precise CAR gene delivery, efficient intracellular expression, and controlled biodistribution for in vivo immune cell reprogramming.
in vivo
Cell Engineering
Cell Engineering
Targeted LNP systems enabling precise CAR gene delivery, efficient intracellular expression, and controlled biodistribution for in vivo immune cell reprogramming.
Gene Therapy
Expert LNP formulation for gene therapy, encapsulating and delivering CRISPR-Cas9 while overcoming degradation and immune recognition.
Gene Therapy
Expert LNP formulation for gene therapy, encapsulating and delivering CRISPR-Cas9 while overcoming degradation and immune recognition.
Gene Silencing
Expert delivery of siRNA and ASOs via LNPs, polymeric nanoparticles, and lipid-polymer hybrids for targeted gene silencing.
Gene Silencing
Expert delivery of siRNA and ASOs via LNPs, polymeric nanoparticles, and lipid-polymer hybrids for targeted gene silencing.
Vaccines
Expertly designed nanoparticles enhancing stability, antigen presentation, and adjuvanticity for targeted immune cell delivery and robust pathogen protection.
Vaccines
Expertly designed nanoparticles enhancing stability, antigen presentation, and adjuvanticity for targeted immune cell delivery and robust pathogen protection.
Immuno-oncology
Our nanoparticles protect immune-modulating cargo and drive targeted accumulation in the tumor microenvironment to enhance anticancer immune activation.
Immuno-oncology
Our nanoparticles protect immune-modulating cargo and drive targeted accumulation in the tumor microenvironment to enhance anticancer immune activation.
Ligand Conjugation
Conjugation of targeting ligands (VHH, mAb, scFv, Fab, peptides) to lipid and polymeric nanoparticles enables precise cellular targeting, maximizes therapeutic impact, and reduces off-target effects.
Ligand Conjugation
Conjugation of targeting ligands (VHH, mAb, scFv, Fab, peptides) to lipid and polymeric nanoparticles enables precise cellular targeting, maximizes therapeutic impact, and reduces off-target effects.
Long-Acting Injectables
Expert polymeric microsphere design enabling sustained small molecule, peptide, and protein release for long-acting injectable applications.
Long-Acting Injectables
Expert polymeric microsphere design enabling sustained small molecule, peptide, and protein release for long-acting injectable applications.
Optimized Nanoparticles for Diverse Therapeutic Payloads
Our scientists are industry leaders designing LNP, polymeric nanoparticle, polymeric microsphere, and lipid-polymer hybrid delivery systems to maximize stability, targeting precision, and therapeutic performance for a range of therapeutic payloads.
- siRNA
- ASO
- mRNA
- DNA
- Small molecules
- Peptides
- Proteins
Core Drug Delivery Solutions
Phosphorex offers expertise in the three dominant non-viral drug delivery platforms, tailoring them to address program-specific needs.
Comprehensive Drug Carriers Engineered for Clinical Success
We design advanced drug carrier systems that protect fragile biologics, control release profiles, and enable precise targeting in complex biological environments. With over 20 years of experience, we develop tailored delivery platforms engineered to enhance stability, optimize biodistribution, and maximize therapeutic efficacy while minimizing off-target effects. Our drug carrier expertise includes our core drug delivery solutions, as well as more specialized options:
- Lipid Nanoparticles
- Liposomes
- Polymeric Nanoparticles
- Polymeric Microspheres
- Micelles
- Lipid-polymer Hybrid
- Polyplexes
THE PHOSPHOREX DRUG DELIVERY ENGINE IN PRACTICE
Long-Acting Peptide Formulation Advanced from Optimization to Phase I
Problem
A partner developing a long-acting peptide therapy for a rare autoimmune disease faced significant formulation and scalability challenges that threatened progress toward clinical development. Existing formulation approaches failed to meet loading, release, and manufacturability requirements needed for IND-enabling studies and clinical supply.
Solution
Phosphorex re-engineered the partner’s formulation, resolving critical technical limitations and establishing a robust, scalable process. The optimized system achieved high peptide loading and encapsulation efficiency with minimal burst release. Phosphorex successfully scaled the formulation and process beyond 300-gram scale, produced GLP preclinical batches to support IND-enabling studies, and executed seamless tech transfer to a GMP manufacturing site.
Outcome
Clinical-grade material was manufactured and released, enabling initiation of a Phase I clinical trial and positioning the program for continued clinical advancement.
Modalities, Payloads & Drug Carriers FAQs
Updates & Expertise
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