Our Story
Pioneering Therapeutics Require Advanced Drug Delivery Solutions
Only a small percentage of early-phase therapeutic assets ever reach the clinic, often stalling due to potency limitations, immunogenicity risks, poor biodistribution, or development processes that cannot scale or withstand regulatory scrutiny.
For more than 20 years, Phosphorex has worked tirelessly, providing essential CDMO services, to change this trajectory. Headquartered in Hopkinton, MA, 26.2 miles from Boston, we integrate advanced drug delivery solutions with scalable process development and CMC strategy to support the transformation of promising therapeutic concepts into clinically viable products.
Mitigating Risk Through Nanoparticle Expertise
With decades of nanoparticle development experience, Phosphorex mitigates risk by aligning biological targets and structure–activity relationships with customized process design, scale-up, and IND strategies. We proactively optimize formulation and downstream conditions, while tightly controlling particle attributes. Ultimately, our consultative process engineers drug delivery systems that preserve performance, control critical quality attributes, and support confident IND filings, bridging the gap between scientific innovation and clinical reality.
Core Drug Delivery Solutions
Phosphorex’s three core drug delivery technologies—lipid nanoparticles, polymeric nanoparticles, and polymeric microspheres—are engineered through a tailored, collaborative approach. By understanding each program’s unique goals, we design custom solutions to enhance bioavailability, targeted delivery, stability, and other key performance objectives necessary for clinical success.
Lipid Nanoparticles (LNPs)
Phosphorex brings extensive expertise in lipid nanoparticle development, enabling efficient delivery of nucleic acids and other relevant payloads through optimized formulation and scalable process design. We craft program-tailored LNPs using advanced analytical techniques to ensure quality, consistency, and performance, while supporting clients across every phase of development, from early feasibility through clinical translation and tech transfer.
Polymeric Nanoparticles (PNPs)
Phosphorex engineers polymeric nanoparticles with customizable targeting, tunable degradation profiles, and enhanced stability to reduce immunogenicity and improve therapeutic performance. Our expertise enables us to support diverse payloads, including nucleic acids, small molecules, peptides, and proteins, while achieving precise organ- and cell-level targeting. Through tailored nanoparticle architectures, we help develop differentiated therapeutic solutions and generate new intellectual property for our partners.
Polymeric Microspheres
Phosphorex develops polymeric microsphere formulations engineered for sustained and long-acting drug release, reducing dosing frequency and improving patient compliance. We incorporate small molecules, peptides, and proteins into biodegradable matrices, tailoring release profiles from one week to several months. Our expertise addresses technical challenges, including maximizing drug loading, minimizing burst release, and controlling degradation to ensure stable, predictable performance.
The Phosphorex Drug Delivery Engine
The Phosphorex Drug Delivery Engine integrates formulation optimization, scalable process design, CMC strategy, analytical expertise, and seamless tech transfer to GMP manufacturing to translate advanced delivery systems from concept to clinic. By aligning science with manufacturability and regulatory readiness, we enable reproducible performance, controlled quality attributes, and clinically viable drug delivery solutions.
Formulation Optimization
We leverage advanced particle engineering and industry-leading expertise to optimize formulations aligned with target product profiles. Through lipid and polymer screening, composition refinement, surface modification, and stability testing, we design scalable, clinically relevant delivery systems.
Process Design & CMC
Analytical Expertise
Tech Transfer, Process Optimization & Troubleshooting
Licenseable LNP Development Services
Phosphorex serves as NOF Corporation's North American center of excellence, evaluating LNP candidates derived from licensable ionizable lipid libraries. Through our partnership, we guide clients from lipid selection, LNP production, high-throughput screening, and candidate nomination. We then facilitate in vivo testing in mice, rats, and non-human primates.
Phosphorex and NOF's joint expertise, coupled with the capabilities of the other LNP Alliance members, offers unmatched knowledge, experience, and seamless completion of IND-enabling studies.
Why Phosphorex for Precision Drug Delivery?
Tailored Approaches
Customized approaches based on your modality, mechanism, and mission
Scalable Solutions
The Phosphorex Drug Delivery Engine provides integrated solutions to drive your program
Precision Targeting
Payload agnostic, precise therapeutic targeting capabilities leveraging the leading non-viral drug delivery technologies
Deep Experience
20 years of experience and expertise
Adaptive Execution
Aligned with the pace of your program, rapidly iterating, realigning, and pivoting as needed
Seamless Partnership
Collaboration and communication that allows us to serve as an extension of your team
Updates & Expertise
Ready to Engineer Particles for Precision Drug Delivery?
Partner with Phosphorex to transform your therapeutic vision into a precisely designed, clinically viable drug delivery solution.