Lipid Nanoparticles
Precision Lipid Nanoparticle Engineered for Clinical Translation
Phosphorex designs and optimizes high-performance lipid nanoparticle (LNP) systems for nucleic acid therapeutics, including mRNA, siRNA, ASO, and gene-editing cargos. By integrating formulation science, scalable process development, analytical rigor, and CMC strategy, we engineer LNPs that overcome biodistribution, potency, and tolerability challenges, ensuring reproducible performance and a streamlined path from early discovery through IND-enabling development and clinical advancement.
A Methodical Journey from Concept to Optimized LNP Formulation
Our LNP formulation screening and optimization services offer a structured approach to systematically evaluating payload-LNP combinations and refining composition and process parameters to identify and optimize clinically viable, high-performing formulations.
Understand Formulation Objectives
Our team collaborates with your team to solidify LNP formulation objectives and your Target Product Profile (TPP).
Explore Payload Candidates
Explore custom payload libraries to screen oligos, mRNA, DNA, or co-encapsulated cargoes with controlled LNP formulations.
Evaluate Drug Delivery Formulation Candidates
Using a single controlled cargo, screen dozens of LNP formulations across diverse lipid compositions; including benchmark ionizable lipids (Dlin-MC3-DMA, SM-102, ALC-0315, LP01, SM-86, Lipid A9) and novel lipids from NOF Corporation (available upon request); to identify top-performing prototypes.
Evaluate Active Targeting
Screen targeting ligands of interest, such as Fab, scFv, VHH nanobodies, peptides, and small molecules, by tethering them to selected LNP compositions and tailoring the conjugation chemistry and conditions to achieve the target product profile.
Formulation and Process Optimization
Formulation optimization systematically refines LNP compositions and process conditions to achieve desired stability, biodistribution, efficacy, manufacturability, and control of critical quality attributes for clinical translation.
Understand Formulation Objectives
Our team collaborates with your team to solidify LNP formulation objectives and your Target Product Profile (TPP).
Explore Payload Candidates
Explore custom payload libraries to screen oligos, mRNA, DNA, or co-encapsulated cargoes with controlled LNP formulations.
Evaluate Drug Delivery Formulation Candidates
Using a single controlled cargo, screen dozens of LNP formulations across diverse lipid compositions; including benchmark ionizable lipids (Dlin-MC3-DMA, SM-102, ALC-0315, LP01, SM-86, Lipid A9) and novel lipids from NOF Corporation (available upon request); to identify top-performing prototypes.
Evaluate Active Targeting
Screen targeting ligands of interest, such as Fab, scFv, VHH nanobodies, peptides, and small molecules, by tethering them to selected LNP compositions and tailoring the conjugation chemistry and conditions to achieve the target product profile.
Formulation and Process Optimization
Formulation optimization systematically refines LNP compositions and process conditions to achieve desired stability, biodistribution, efficacy, manufacturability, and control of critical quality attributes for clinical translation.
Understand Formulation Objectives
Our team collaborates with your team to solidify LNP formulation objectives and your Target Product Profile (TPP).
Explore Payload Candidates
Explore custom payload libraries to screen oligos, mRNA, DNA, or co-encapsulated cargoes with controlled LNP formulations.
Evaluate Drug Delivery Formulation Candidates
Using a single controlled cargo, screen dozens of LNP formulations across diverse lipid compositions; including benchmark ionizable lipids (Dlin-MC3-DMA, SM-102, ALC-0315, LP01, SM-86, Lipid A9) and novel lipids from NOF Corporation (available upon request); to identify top-performing prototypes.
Evaluate Active Targeting
Screen targeting ligands of interest, such as Fab, scFv, VHH nanobodies, peptides, and small molecules, by tethering them to selected LNP compositions and tailoring the conjugation chemistry and conditions to achieve the target product profile.
Formulation and Process Optimization
Formulation optimization systematically refines LNP compositions and process conditions to achieve desired stability, biodistribution, efficacy, manufacturability, and control of critical quality attributes for clinical translation.
The Phosphorex Drug Delivery Engine for LNPs
Advancing LNP-based therapeutics from promising biology to clinical success demands integrated formulation optimization, scalable process development, CMC strategy, analytical rigor, and disciplined tech transfer. The Phosphorex Drug Delivery Engine unifies these capabilities to translate high-performing LNP systems into reproducible, regulatory-ready therapies built for clinical advancement.
Formulation Optimization
We drive the design of precise, scalable LNP formulations systematically evaluating payload-drug delivery formulation combinations and refining composition and process parameters to identify and optimize clinically viable, high-performing formulations.
Process Design & CMC
Analytical Expertise
Tech Transfer, Process Optimization & Troubleshooting
Why Phosphorex for LNPs?
20+ Years of Drug
Delivery Leadership
Two decades of nanoparticle development experience translating complex therapeutics into clinically viable products.
Access to Proprietary
Ionizable Lipids
As the NOF Corporation's North American LNP Center of Excellence, we enable the evaluation of advanced, licensable lipid libraries to engineer high-performing LNP systems.
Multiple In-House Mixing
Technologies
Utilization of microfluidics, T-mixers, and impingement jet mixers to tailor particle formation and scale-up strategy.
Downstream
Processing Depth
Extensive expertise in tangential flow filtration (TFF), concentration, purification, sterile filtration, and scalable recovery of high-quality LNPs.
Comprehensive,
Stage-Appropriate Analytics
Robust characterization and stability strategies aligned with the development phase and regulatory expectations.
Collaborative & Flexible Support
Collaboration drives agile iteration, rapid realignment, and seamless progression from formulation screening through IND-enabling scale-up and clinical manufacturing.
20+ Years of Drug
Delivery Leadership
Downstream
Processing Depth
Access to Proprietary
Ionizable Lipids
Comprehensive,
Stage-Appropriate Analytics
Multiple In-House Mixing
Technologies
Collaborative & Flexible Support
NOF Corporation's North American LNP Center of Excellence
In addition to evaluating NOF's proprietary, licensable ionizable lipid libraries, our strategic partnerships with other members of the LNP Alliance allow us to offer integrated expertise and an accelerated path to clinical readiness, guiding clients from lipid selection and high-throughput screening to in vivo validation and IND-enabling development.
THE PHOSPHOREX DRUG DELIVERY ENGINE IN PRACTICE
Rapid Benchmarking Identifies High-Expression LNP and Enables Scale-Up
Problem
A client developing a gene-editing therapy needed to rapidly identify an LNP formulation that delivers optimal in vivo expression while remaining suitable for downstream scale-up. With multiple benchmark lipid systems available, selecting the right formulation early was critical to avoid delays and unnecessary development risk.
Solution
Phosphorex fabricated and evaluated six benchmark LNP formulations, optimizing formulation buffers for each system to align with the target product profile. Five optimized formulations were advanced to 1 mg batch-scale production to supply in vivo mouse efficacy studies, enabling direct comparison of expression performance under consistent conditions.
Outcome
The highest-performing formulation was identified based on in vivo expression data. The program advanced immediately to process scale-up, with Phosphorex producing an 85 mg batch of the selected formulation to support a subsequent rodent study, accelerating development timelines and reducing formulation uncertainty.
Lipid Nanoparticle FAQs
Updates & Expertise
Ready to Engineer Particles for Precision Drug Delivery?
Partner with Phosphorex to transform your therapeutic vision into a precisely designed, clinically viable drug delivery solution.