The Phosphorex Drug Delivery Engine
Driving Force of High-Performance Drug Delivery
Bridging the gap between promising biology, encouraging preclinical data, and clinical reality is often not straightforward, particularly when developing advanced therapeutics. In this space, drug delivery system design can be the cause or the cure for potency limitations, immunogenicity risks, and poor biodistribution.
The Phosphorex Drug Delivery Engine offers extensive experience and expertise to achieve scalability, reproducibility, and quality, while ensuring drug product performance and control of critical quality attributes.
The Phosphorex Drug Delivery Engine Powers Your Path to the Clinic
Designing the right drug-delivery solution for your molecule is critical to addressing potency, biodistribution, and patient-safety challenges. The Phosphorex Drug Delivery Engine leverages our core drug delivery technologies to optimize therapeutic performance, minimize systemic risks for patients, and ensure a scalable, commercializable process design.
Formulation Optimization
We harness advanced particle engineering and industry-leading instrumentation to optimize formulations aligned with target product profiles. Through lipid and polymer screening, composition refinement, surface modification, and stability testing, we design scalable, clinically relevant delivery systems.
Process Design & CMC
Analytical Expertise
Tech Transfer, Process Optimization & Troubleshooting
Core Drug Delivery Solutions
Phosphorex offers expertise in the three dominant non-viral drug delivery platforms, tailoring them to address program-specific needs.
THE PHOSPHOREX DRUG DELIVERY ENGINE IN PRACTICE
Rapid Benchmarking Identifies High-Expression LNP and Enables Scale-Up
Problem
A client developing a gene-editing therapy needed to rapidly identify an LNP formulation capable of delivering optimal in vivo expression while remaining suitable for downstream scale-up. With multiple benchmark lipid systems available, selecting the right formulation early was critical to avoid delays and unnecessary development risk.
Solution
Phosphorex fabricated and evaluated six benchmark LNP formulations, optimizing formulation buffers for each system to align with the target product profile. Five optimized formulations were advanced to 1 mg batch-scale production to supply in vivo mouse efficacy studies, enabling direct comparison of expression performance under consistent conditions.
Outcome
The highest-performing formulation was identified based on in vivo expression data. The program immediately advanced to scale-up, with Phosphorex producing an 85 mg batch of the selected formulation to support a subsequent rodent study, thereby accelerating development timelines and reducing formulation uncertainty.
The Phosphorex Drug Delivery Engine FAQs
Updates & Expertise
Ready to Engineer Particles for Precision Drug Delivery?
Partner with Phosphorex to transform your therapeutic vision into a precisely designed, clinically viable drug delivery solution.