Preparation of Actively Targeted LNPs Through mAb Surface Conjugation Via Strain-promoted Azide-alkyne Click Chemistry (SPAAC)
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Preparation of Actively Targeted LNPs Through mAb Surface Conjugation Via Strain-promoted Azide-alkyne Click Chemistry (SPAAC)

Introduction

Lipid nanoparticles (LNPs) have great promise for treating various diseases and genetic conditions. They naturally accumulate in the liver, making them ideal for delivering therapeutics to treat hepatic diseases. However, achieving efficient extra-hepatic delivery remains a significant challenge, limiting their broader clinical applications.

Several strategies can help modulate LNP biodistribution, including incorporating selective organ targeting (SORT) lipids, adjusting PEG content, and optimizing particle size and surface charge. Additionally, functionalizing LNP surfaces with targeting moieties can enhance their specificity for particular cells or tissue types. For instance, conjugating antibodies to LNPs that bind specific antigens or cell surface receptors can improve targeted delivery to diseased tissues.

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